Status:
NOT_YET_RECRUITING
Neurolytic Block Techniques In Abdominal Visceral Cancer Pain
Lead Sponsor:
Instituto do Cancer do Estado de São Paulo
Conditions:
Cancer, Malignant Tumors
Abdominal Cancer
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The neurolytic blocks of sympathetic chains are commonly used for the treatment of cancer-related pain. This study aims to compare celiac plexus neurolysis and splanchnic nerve neurolysis for the trea...
Detailed Description
Double-blind randomized clinical trial. The objective of the study is to compare the analgesic efficacy of splanchnic nerve neurolysis with alcohol to celiac plexus block with alcohol, with pain reli...
Eligibility Criteria
Inclusion
- Patients aged 18 years or older Presence of localized visceral pain in the upper abdomen originating from cancer of the stomach, duodenum, distal esophagus, ascending or transverse colon, liver, biliary tract, or pancreas
- Ineffectiveness of analgesic treatment with third-step opioids according to the WHO analgesic ladder, including:
- Opioids (≥ 60 mg/day of morphine equivalents) Antidepressants (tricyclic or dual-action), at any dosage Gabapentinoids, at any dosage Presence of side effects from analgesics that are difficult to manage with medication
Exclusion
- Presence of ascites Presence of deep vein thrombosis Presence of hepatic failure: Child-Pugh class B or C Presence of renal failure: estimated glomerular filtration rate (eGFR) \< 60 ml/min/1.73 m² Use of any anticoagulant medication
- Clinical coagulation disorder, defined as:
- INR \> 1.5 Prothrombin activity \< 70% or prothrombin time \> 13.5 seconds aPTT \> 40 seconds Cardiovascular failure: NYHA class III
Key Trial Info
Start Date :
May 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT06978673
Start Date
May 30 2025
End Date
December 1 2026
Last Update
June 3 2025
Active Locations (1)
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1
Instituto de Cancer Do Estado
São Paulo, São Paulo, Brazil, 01246-000