Status:
RECRUITING
Research for Plasma Biomarkers Associated With Fatigue in Thrombocytopenic Patients
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Conditions:
Thrombopenia
Eligibility:
All Genders
8+ years
Phase:
NA
Brief Summary
Thrombocytopenia is a clinical problem defined by a platelet count lower than 150×10⁹/L. It can be linked to various pathologies of central origin, such as decreased platelet production in the bone ma...
Detailed Description
Thrombocytopenia is defined as a platelet count below 150×109/L. The mechanisms leading to thrombocytopenia are multiple, and may be linked to : * reduced platelet production in the bone marrow; * in...
Eligibility Criteria
Inclusion
- Inclusion criteria for patients (adults or minors):
- Patients with constitutional or autoimmune (chronic or persistent ITP with last treatment administration ≥ 3 weeks) thrombocytopenia (platelet count \< 150×109/L) already diagnosed
- patient not being treated and not receiving serotonin reuptake inhibitor (SSRI) or norepinephrine (SNRI) or antithrombotic treatments (antiplatelet or anticoagulant) in the 10 days prior to inclusion
- affiliation to social security (beneficiary or assignee)
- patient followed in consultation in one of the recruiting haematology departments
- Patient (or parent) having received a detailed explanation of the research project and having consent by signing the consent form before any research-specific procedure
- Inclusion criteria for healthy volunteers:
- Age- (± 5 years) and sex-matched healthy adult controls
- Non-thrombocytopenic patients and not receiving antithrombotic, SNRI or SSRI therapy or if applicable, last treatment ≥ 10 days
- affiliation to social security (beneficiary or assignee)
- adults who received a detailed explanation of the research project and having consent by signing the consent form before any research-specific procedure
- Non inclusion criteria (adults and minors):
- Adult patients under legal protection (guardianship or curatorship) Thrombocytopenic patients treated with antithrombotics, serotonin reuptake inhibitors (SSRIs) or noradrenaline reuptake inhibitors (SNRIs)
- Minor patients weighing less than 20 kg
- Non inclusion criteria for healthy adult controls:
- Healthy adult volunteers under legal protection (guardianship, curatorship or safeguard of justice).
- Pregnant women
Exclusion
Key Trial Info
Start Date :
March 26 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 26 2028
Estimated Enrollment :
280 Patients enrolled
Trial Details
Trial ID
NCT06979765
Start Date
March 26 2025
End Date
June 26 2028
Last Update
May 20 2025
Active Locations (1)
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1
Hôpital Bichat-Claude Bernard
Paris, France, 75018