Status:
RECRUITING
Neural Mechanisms of Interpersonal Expectations on Negative Affect
Lead Sponsor:
Trustees of Dartmouth College
Conditions:
Negative Affectivity
Non-invasive Brain Stimulation
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn whether non-invasive brain stimulation, called transcranial temporal interference stimulation (tTIS), can reduce negative affect, and how expectations shape...
Detailed Description
The study employs a within-subject, crossover factorial design, consisting of two experiments. Experiment 1 In Experiment 1, 30 participants ('patients') will complete all combinations of two indepe...
Eligibility Criteria
Inclusion
- 'Doctors' are recruited from medical students at the Geisel School of Medicine and resident physicians at Dartmouth Hitchcock Medical Center (DHMC).
Exclusion
- No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis
- No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment
- No self-reported current chronic pain, or acute pain within three months of the study period
- No current migraine disorder (i.e., 15 headache days or more in 1 month)
- No use of central nervous system-effective medication or other medication for neurological/psychiatric treatment
- No self-reported substance abuse within the last six months
- No contraindication to MRI or tTIS (e.g., pregnancy, claustrophobia, pacemakers, ear/cochlear implants, shrapnel injuries, clips, or other ferromagnetic/electrical objects/devices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)
- No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)
- Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English
- Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 3 2027
Estimated Enrollment :
190 Patients enrolled
Trial Details
Trial ID
NCT06980090
Start Date
September 1 2025
End Date
March 3 2027
Last Update
December 9 2025
Active Locations (1)
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1
Dartmouth College, Department of Psychological and Brain Sciences
Hanover, New Hampshire, United States, 03755