Status:
RECRUITING
SSTR2 Imaging With [68Ga]Ga-DOTA-TOC PET/CT in NPC
Lead Sponsor:
University Medical Center Groningen
Conditions:
Nasopharyngeal Carcinoma (NPC)
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
This is an investigator-initiated, single-center clinical trial designed to evaluate the feasibility of \[68Ga\]Ga-DOTA-TOC positron emission tomography (PET) scan in patients with Epstein-Barr virus ...
Eligibility Criteria
Inclusion
- Stage IB-IVA NPC (AJCC 9th edition), EBV positive determined by Epstein-Barr virus-encoded RNA (EBER).
- Planned treatment with induction chemotherapy or CRT without induction chemotherapy.
- Age ≥ 18 years.
- Signed informed consent.
- Willingness and ability to comply with all protocol required procedures.
- Negative serum pregnancy test at screening in women of childbearing potential.
- Archival tumor tissue available or consent to undergo a tumor biopsy procedure.
Exclusion
- Previous treatment with chemotherapy or radiotherapy for NPC.
- Treatment with any investigational agent or participation in another clinical trial with therapeutic intent within 28 days prior to \[68Ga\]Ga-DOTA-TOC injection.
- Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or that may affect the interpretation of the results or render the patient at high risk from complications.
- Altered mental status, or any psychiatric condition that would prohibit the understanding or rendering of informed consent.
- Inability to lie in supine position for 25 minutes.
- Patients who are pregnant or breastfeeding.
Key Trial Info
Start Date :
September 25 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT06982300
Start Date
September 25 2025
End Date
December 1 2026
Last Update
October 3 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ