Status:
COMPLETED
Study to Investigate the Potential Health Benefits of Grapes Seeds Extract Supplementation in the Management of Elevated Blood Pressure or Stage 1 Hypertension
Lead Sponsor:
Liaquat University of Medical & Health Sciences
Conditions:
Elevated Blood Pressure
Hypertension
Eligibility:
All Genders
30-65 years
Phase:
NA
Brief Summary
This study is a pragmatic, randomized, double-blind, placebo-controlled trial aimed at evaluating the potential health benefits of Enovita® (standardized grape seed extract) supplementation in adults ...
Detailed Description
Hypertension is a major risk factor for cardiovascular diseases, and its early management is crucial. Grape seed extract is a natural polyphenol-rich supplement that may offer antihypertensive benefit...
Eligibility Criteria
Inclusion
- Adults aged 30 to 65 years.
- Diagnosed with Elevated Blood Pressure (systolic 120-129 mmHg and diastolic \<80 mmHg) or Stage 1 Hypertension (systolic 130-139 mmHg or diastolic 80-89 mmHg), according to American Heart Association guidelines.
- No use of antihypertensive medication in the past 3 months.
- Willing to comply with study procedures and follow-up visits.
- Able to provide written informed consent.
Exclusion
- Stage 2 Hypertension (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) at screening.
- Chronic kidney disease (eGFR \< 60 mL/min/1.73 m²).
- Diabetes mellitus (HbA1c ≥ 6.5%).
- History of cardiovascular events (myocardial infarction, stroke) in the past 6 months.
- Known allergy to grape products.
- Current use of polyphenol supplements or similar herbal products.
- Pregnancy or breastfeeding.
- Participation in another clinical trial within the last 30 days.
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 27 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06982365
Start Date
August 1 2025
End Date
November 27 2025
Last Update
December 5 2025
Active Locations (1)
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1
Liaquat University of Medical & Health Sciences (LUMHS)
Jāmshoro, Sindh, Pakistan, 76090