Status:
RECRUITING
Accelerated TMS for Freezing of Gait in Parkinson's Disease
Lead Sponsor:
Medical University of South Carolina
Conditions:
Parkinson's Disease (PD)
Eligibility:
All Genders
50-80 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to learn whether a personalized brain stimulation method called repetitive transcranial magnetic stimulation (rTMS), combined with walking exercises, is a practical ...
Eligibility Criteria
Inclusion
- 50-80 years of age
- diagnosis of PD based on UK Brain Bank diagnostic criteria 55
- presence of FOG defined as a score of 1 on part 1 of the nFOGQ in which a video showing different types of freezing is played for the patient, a score of 1 represents a positive response of having experienced such an episode over the last month
- no dopaminergic medication changes in the month prior
- observed FOG rated as \>1 in item 3.11 of the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS).
Exclusion
- a history of other significant gait impairment unrelated to PD (e.g. orthopedic deformities)
- inability to complete gait assessments (timed up and go task) without assistance or assist devices
- barriers to making contact between the TMS coil and the skin (e.g. braids that cannot be removed)
- failing to meet all criteria on a standardized MRI/TMS safety screening: This includes, but is not limited to, the presence of claustrophobia, implanted electronic devices (e.g., pacemakers), metallic objects or fragments (e.g., bullets), and non-removable hair clips or piercings.
- individuals with a diagnosis of psychosis or any other cognitive impairments that would make them unable to understand and follow study instructions or to consent for themselves.
- pregnancy
- individuals with a history of seizure
Key Trial Info
Start Date :
November 21 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT06982638
Start Date
November 21 2024
End Date
December 31 2026
Last Update
January 7 2026
Active Locations (1)
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1
Medical University of South Carlina
Charleston, South Carolina, United States, 29414