Status:
RECRUITING
How Epigenetic Changes in hMLH1 Connect Lab Research With Diagnosis in Gastric Cancer
Lead Sponsor:
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Conditions:
Gastrectomy for Gastric Cancer
Gastrectomy
Eligibility:
All Genders
18+ years
Brief Summary
DNA methylation is one of the key mechanisms that are thought to underlie the association between aging and cancer. Several methylation-based measures of biological aging have been developed and have ...
Eligibility Criteria
Inclusion
- Patients who underwent elective gastrectomy for Stage I-IV gastric cancer.
- Surgery performed at the General Surgery Unit of Fondazione Policlinico Universitario A. Gemelli IRCCS.
- Procedures conducted between January 2017 and August 2023.
- Only patients who have already undergone immunohistochemistry evaluation for expression of the components of the MMR complex (MLH1, PMS2, MSH2, and MSH6).
Exclusion
- \- Patients with missing immunohistochemistry evaluation for the expression of the components of the MMR complex (MLH1, PMS2, MSH2, and MSH6).
Key Trial Info
Start Date :
September 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 30 2026
Estimated Enrollment :
245 Patients enrolled
Trial Details
Trial ID
NCT06982768
Start Date
September 1 2024
End Date
April 30 2026
Last Update
January 2 2026
Active Locations (1)
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1
UOC Chirurgia Generale 1 - Fondazione Policlinico Universitario A. Gemelli IRCCS
Rome, Italy, 00168