Status:
COMPLETED
Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome
Lead Sponsor:
Mansoura University
Conditions:
Euthyroid Sick Syndrome
Obesity Hypoventilation Syndrome (OHS)
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational study is to learn about the frequency and clinical impact of Euthyroid Sick Syndrome (ESS) in patients with Obesity Hypoventilation Syndrome (OHS) who are admitted to th...
Detailed Description
Obesity Hypoventilation Syndrome (OHS) is a serious respiratory condition that often requires ICU admission during acute decompensation. Emerging evidence suggests a potential link between systemic hy...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Diagnosis of Obesity Hypoventilation Syndrome (OHS), either pre-existing or newly established during ICU admission
- Admitted to the intensive care unit (ICU) with acute hypercapnic respiratory failure, defined as:
- Arterial pH \< 7.35
- PaCO₂ \> 45 mmHg
- Thyroid function tests performed within 24 hours of ICU admission
- Written informed consent provided by patient
Exclusion
- Known history of thyroid disease (e.g., hypothyroidism, hyperthyroidism, thyroiditis, central hypothyroidism)
- Presence of acute conditions known to affect thyroid function tests, including:
- Sepsis
- Pneumonia
- Active malignancy
- Liver cirrhosis
- Kidney failure
- Heart failure
- Use of medications affecting thyroid function, including:
- Corticosteroids
- Amiodarone
- Iodinated contrast agents
Key Trial Info
Start Date :
September 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 30 2023
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT06983418
Start Date
September 1 2021
End Date
October 30 2023
Last Update
May 21 2025
Active Locations (1)
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1
Faculty of Medicine Mansoura University
Al Mansurah, Dakahlia/Egypt, Egypt, 35511