Status:
NOT_YET_RECRUITING
The Kidney's Response to Exercise in Heat, and the Impact of Vitamin B3 on This Response
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
Boston University Charles River Campus
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Conditions:
Heat Strain
Healthy Volunteer Study
Eligibility:
All Genders
18-45 years
Phase:
EARLY_PHASE1
Brief Summary
The goal of this clinical trial is to learn about the processes occurring in the kidneys while under heat stress in healthy volunteers. The main questions it aims to answer are: * How do the chemical...
Detailed Description
To answer these questions, researchers will compare the chemical changes in each participant under progressively higher levels of heat stress, and while taking either vitamin B3 or a placebo. This cl...
Eligibility Criteria
Inclusion
- Healthy volunteer
- Any race
- Estimated glomerular filtration rate greater than 90 ml/min/1.73m2
- Urine albumin/creatinine ratio less than 30mg/g
- Nonsmoker
- No regular dietary supplements, particularly vitamin B3
- Physically fit, defined as having a VO2 max of between 35 and 60mL/kg/min
Exclusion
- Medical condition preventing safe participation in exercise during heat
- Allergy to Vitamin B3
- Severe food allergies or dietary restrictions that would preclude eating the planned study diet without major modifications
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2028
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT06983730
Start Date
January 1 2026
End Date
June 1 2028
Last Update
January 8 2026
Active Locations (2)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
2
Boston University
Boston, Massachusetts, United States, 02215