Status:
ACTIVE_NOT_RECRUITING
Evaluation of Salivary and Serum Levels of TNF-α, IL-17A, and YKL-40 in Individuals With Psoriasis
Lead Sponsor:
Akdeniz University
Conditions:
Periodontitis
Psoriasis
Eligibility:
All Genders
18-65 years
Brief Summary
Background: Periodontitis is a chronic inflammatory disease triggered by microbial infections that lead to the destruction of tissues supporting the teeth. Psoriasis is a chronic skin condition charac...
Detailed Description
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, characterized by gingival inflammation, destruction of periodontal tissues, and alveolar bone loss. Th...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Voluntary participation
- No use of antibiotics within the past 6 months
- No periodontal treatment within the past 6 months
- Absence of systemic diseases known to affect periodontal health (e.g., diabetes, cardiovascular diseases)
- No infectious diseases such as tuberculosis, hepatitis, or AIDS
- Age 18 years or older
- Not pregnant (for female participants)
- Exclusion Criteria:
- Pregnancy or ongoing lactation
- History of gingival treatment within the past 6 months
- History of any disease involving the oral mucosa (e.g., lichen planus, pemphigus vulgaris, chronic ulcerative stomatitis)
- Current use of systemic corticosteroids, immunosuppressive agents, or biological drugs
- History of systemic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, irritable bowel syndrome, diabetes mellitus)
- Fewer than 20 natural teeth (excluding third molars)
- Current smokers
- Age younger than 18 or older than 65 years
Exclusion
Key Trial Info
Start Date :
December 2 2024
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 1 2025
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT06984237
Start Date
December 2 2024
End Date
May 1 2025
Last Update
May 22 2025
Active Locations (1)
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1
Akdeniz University, Fculty of Dentistry, Akdeniz University Hospital
Antalya, Turkey (Türkiye), 07070