Status:
RECRUITING
Vascular Function and Oxidative Stress in Emergency Medical Responders
Lead Sponsor:
University of Delaware
Conditions:
Cardiovascular Function in EMTs
Eligibility:
All Genders
20-40 years
Phase:
NA
Brief Summary
The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs). The main que...
Detailed Description
Heart disease, also referred to as cardiovascular disease, is the leading cause of death worldwide, responsible for about 30% of all deaths. While eating right, staying active, and avoiding cigarettes...
Eligibility Criteria
Inclusion
- Body mass index between 18.5 and \<35 kg/m²
- Seated resting systolic blood pressure \< 140 mmHg, and seated resting diastolic blood pressure \< 90 mmHg
- Participant must be an active first responder that works shift work schedules. e.g., emergency medical responders, basic life support emergency medical technicians (i.e., BLS EMT), advanced life support emergency medical technicians (A-EMT), and paramedics
- Participant must have been working shift work for at least 1 year
- Participant must work at least 4 night shifts per month
Exclusion
- Participant is unwilling or unable to give consent
- Participant has been diagnosed with any chronic disease (a history of high blood pressure, heart disease, diabetes, cancer, kidney disease)
- Participant has been diagnosed with a sleep disorder (e.g., insomnia, restless leg syndrome, sleep apnea)
- Participant is currently taking melatonin or other sleep aids (e.g., Ambien, sedatives, etc.), or any supplements/medications known to alter sleep patterns. Participants using melatonin must undergo a minimum 72-hour washout period prior to study participation to ensure baseline sleep patterns are not affected\[15, 16\]
- Resting blood pressure \>140/90 mmHg
- Body mass index \<18.5 or \>35 kg/m2
- Currently pregnant or breast feeding (women only)
- Currently use tobacco or nicotine products (≥1 cigarette, cigar, e-cigarette, vape, or any other nicotine-containing product in the last month), including smokeless tobacco (e.g., chewing tobacco, snuff, dip, snus), nicotine lozenges or gum, heated tobacco products, and any illicit drugs
Key Trial Info
Start Date :
May 14 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2025
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06985394
Start Date
May 14 2025
End Date
October 1 2025
Last Update
May 22 2025
Active Locations (1)
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1
University of Delaware
Newark, Delaware, United States, 19713