Status:
RECRUITING
CKD Cachexia and Gut Microbiome
Lead Sponsor:
Université Catholique de Louvain
Collaborating Sponsors:
Fonds National de la Recherche Scientifique
FRC- Fonds de la Recherche Clinique
Conditions:
Chronic Kidney Diseases
Cachexia
Eligibility:
All Genders
18+ years
Brief Summary
Cachexia is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality. Cachexia is a complex syndrome, in which inflammation and retention of uremic...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Diagnosis of kidney failure (stage V)
- Maintenance dialysis for at least 3 months
- Understanding of the trial procedures and ability to adhere to the trial protocol
Exclusion
- Severe nonadherence to the dialysis procedure
- Life expectancy below 1 year
- Chronic inflammatory disease of the digestive tract (Crohn's disease, ulcerative colitis)
- Bariatric surgery
- Active cancer
- Pregnancy
- Antibiotics consumption in the month preceding the inclusion
- Gastro-intestinal surgery, colonoscopy, or probiotics consumption in the 3 months preceding the inclusion
- Drugs influencing body composition initiated ≤ 1 month : systemic corticosteroids, anabolic drugs as insulin or testosterone, post-menopausal hormone therapy, injectable contraceptives.
- Known endocrinological disorders potentially leading to hypo- or hypermetabolism, untreated or treated for ≤ 1 month : disorders of thyroid gland, adrenal glands...
- Patients under weight loss drugs : GLP1 agonists, orlistat
Key Trial Info
Start Date :
February 4 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2030
Estimated Enrollment :
157 Patients enrolled
Trial Details
Trial ID
NCT06986265
Start Date
February 4 2025
End Date
December 1 2030
Last Update
May 22 2025
Active Locations (2)
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1
Cliniques universitaires Saint-Luc
Brussels, Belgium, 1200
2
UCLouvain
Brussels, Belgium, 1200