Status:
COMPLETED
Role of Inflammasome in Platelet Activation in Sickle Cell Disease Patient
Lead Sponsor:
Centre Hospitalier Universitaire de la Guadeloupe
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
18+ years
Brief Summary
Sickle cell disease is characterized by chronic hemolytic anemia, painful crisis called vaso-occlusive crisis and chronic inflammation. Activated platelets of Sickle cell disease patients participated...
Detailed Description
During inflammation, platelets are activated through different cell signaling pathways, all of them leading to P selectin expression. Platelets activated by intravascular hemolysis (hemoglobin and hem...
Eligibility Criteria
Inclusion
- patients with SS or SC Sickle cell disease
- diagnosis of SCD performed by electrophoresis or HPLC in a reference laboratory for hemoglobinopathies
- clinically in a steady state at inclusion (without complication in the last month and without transfusion in the three last months)
- patient followed up for Sickle cell disease at the sickle cell center of Guadeloupe (University hospital of Guadeloupe, Pointe à Pitre)
- patients who will provide written informed consent in accordance with the Declaration of Helsinki
- patients affiliated to national social security
Exclusion
- \- patients with hemoglobinopathy other than SS and SC Sickle cell disease
- patients with a transfusion therapy or on bleeding therapy for less than three months
- patients no affiliated to national social security
- pregnant or breastfeeding patients
- patients who will not provide written informed consent in accordance with the Declaration of Helsinki
Key Trial Info
Start Date :
October 14 2020
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 20 2024
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT06986837
Start Date
October 14 2020
End Date
April 20 2024
Last Update
May 23 2025
Active Locations (1)
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1
Chu de La Guadeloupe
Pointe-à-Pitre, Guadeloupe, 97159