Status:
RECRUITING
MEP Up-conditioning to Target Corticospinal Plasticity
Lead Sponsor:
Medical University of South Carolina
Collaborating Sponsors:
Doscher Neurorehabilitation Research Program
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Spinal Cord Injury
Tetraplegia/Tetraparesis
Eligibility:
All Genders
18+ years
Phase:
EARLY_PHASE1
Brief Summary
Individuals with chronic cervical spinal cord injury will complete a 10-week training protocol where participants receive non-invasive brain stimulation and feedback on the size of the corresponding m...
Detailed Description
Corticospinal function is essential in generating and controlling voluntary movements. Cervical spinal cord injury (SCI) disrupts corticospinal connections, therefore, often results in weak voluntary ...
Eligibility Criteria
Inclusion
- Adult (≥18 yrs old)
- A history of injury to spinal cord at or above C6
- \>6 months post SCI
- Weak wrist extension at least unilaterally
- Expectation that current medication will be maintained without change for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted.
Exclusion
- Motoneuron injury
- Medically unstable condition
- Cognitive impairment
- A history of epileptic seizures
- Metal implants in the cranium
- Implanted biomedical device in or above the chest (e.g., a cardiac pacemaker, cochlear implant)
- Extensive use of functional electrical stimulation to the arm on a daily basis
- Pregnancy (due to changes in posture and potential medical instability)
- Contraindications to MRI
- No measurable MEP elicited in the ECR
- Unable to produce any voluntary ECR EMG activity
Key Trial Info
Start Date :
May 27 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2027
Estimated Enrollment :
11 Patients enrolled
Trial Details
Trial ID
NCT06989905
Start Date
May 27 2025
End Date
March 31 2027
Last Update
May 31 2025
Active Locations (1)
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1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425