Status:
NOT_YET_RECRUITING
Effect of Salidroside on Pregnancy Outcomes in High Childbearing Age Patients in Viro Fertilization
Lead Sponsor:
The Second Hospital of Shandong University
Conditions:
Salidroside
Randomized Controlled Trial
Eligibility:
FEMALE
35-39 years
Phase:
PHASE2
Brief Summary
With the decreasing of birth rate and population in our country, population problem has become a long-term and strategic problem. In addition to the decrease in the number of women of childbearing age...
Detailed Description
With the continuous decline in China's birth rate and number of births in recent years, the population issue has become a long-term and strategic issue in China. In addition to the impact of the decre...
Eligibility Criteria
Inclusion
- Age ≥35 and \< 40 years old
- For the first or second cycle of IVF, ICSI or IVF with donor sperm
- According to the 2016 Poseton criteria for poor prognosis: the number of oocytes obtained in the previous routine ovulation induction protocol was 1-9, or AFC \< 5 or AMH \< 1.2ng/ml (measured within the past half year) in both ovaries.
Exclusion
- Patients with coagulation disorders
- Patients with previous abnormal uterine bleeding
- Combined with hydrosalpinx confirmed by B-ultrasound and HSG
- Uterine malformation (unicornuate uterus, septate uterus) or history of intrauterine adhesions
- Patients with previous spontaneous abortion ≥3 times
- Patients with contraindications to assisted reproductive technology or pregnancy
- Previous or current oral medication containing salidroside
- The controlled ovarian stimulation protocol included PPOS protocol, luteal phase ovulation induction protocol, and continuous stimulation protocol
Key Trial Info
Start Date :
June 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
370 Patients enrolled
Trial Details
Trial ID
NCT06990685
Start Date
June 1 2025
End Date
December 1 2027
Last Update
May 25 2025
Active Locations (1)
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1
The Second Hospital of Shandong University,
Jinan, Shandong, China