Status:
COMPLETED
Effect of Low Molecular Weight Heparin in Freeze-thaw Embryo Transfer Cycles in Women With Recurrent Implantation Failure
Lead Sponsor:
The Second Hospital of Shandong University
Conditions:
Low Molecular Weight Heparin
Recurrent Implantation Failure
Eligibility:
FEMALE
20-40 years
Brief Summary
Recurrent implantation failure (RIF) is considered a tough problem in assisted reproductive technology (ART) without effective treatments. The effect of low molecular weight heparin (LMWH) in pregnanc...
Eligibility Criteria
Inclusion
- Women under or equal to the age of 40 when oocytes were retrieved;
- The history of at least 2 failed fresh embryo transfer/FET cycles and cumulative transfer of ≥ 3 high-quality embryos or cumulative transfer of ≥ 2 blastocysts;
- Planning to FET after IVF or ICSI cycles
Exclusion
- Women with untreated hydrosalpinx, uterine cavity occupying lesions (uterine adhesions, submucous fibroids, endometrial polyps, et al.);
- Women with abnormal anatomical structure of uterus (unicornuate uterus, bipedal uterus, et al.);
- Women with endometrial thickness (EMT) \< 6mm on the day of transplantation;
- Women or their partner with abnormal chromosome karyotype (not including chromosome polymorphisms);
- Women with the history of recurrent spontaneous abortion (RSA);
- Women with a history of autoimmune or coagulation disorders;
- Women with contraindications to LMWH
Key Trial Info
Start Date :
January 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2025
Estimated Enrollment :
392 Patients enrolled
Trial Details
Trial ID
NCT06991530
Start Date
January 1 2021
End Date
March 1 2025
Last Update
August 12 2025
Active Locations (1)
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1
The Second Hospital of Shandong University
Jinan, Shandong, China