Status:
NOT_YET_RECRUITING
Immune-targeted Combination With Chemotherapy for Acute Leukemia of Ambiguous Lineage
Lead Sponsor:
Institute of Hematology & Blood Diseases Hospital, China
Conditions:
Adult ALL
MPAL
Eligibility:
All Genders
14+ years
Phase:
NA
Brief Summary
Acute leukemia of ambiguous lineage (ALAL), which refers to acute leukemia without definite evidence indicating cell differentiation along a specific lineage, mainly encompasses two major categories: ...
Eligibility Criteria
Inclusion
- A series of acute leukemia of unknown origin diagnosed in accordance with the 5th edition of the WHO or ICC classification standards.
- Age ≥ 14 years old, regardless of gender.
- The ECOG performance status score is ≤ 2.
- Conform to the following organ functional status: total bilirubin \< 1.5×ULN, AST and ALT ≤ 2.5×ULN; blood Cr \< 1.5×ULN; myocardial enzymes \< 2×ULN; serum amylase ≤ 1.5×ULN; echocardiography indicates that the left ventricular ejection fraction (LEF) \> 50%. (In the case of patients without a previous history of liver or kidney basic disease, if liver and kidney function abnormalities exceed the aforementioned inclusion criteria and the researcher determines that the liver and kidney function abnormalities are caused by acute leukemia itself, they may be included in the group at the researcher's discretion).
- Understand and sign the informed consent form and agree to abide by the research requirements.
Exclusion
- Concurrent with other serious and/or uncontrollable underlying diseases: accompanied by other malignant diseases requiring treatment, acute or chronic hepatitis, severe pancreatic or kidney diseases; other serious and/or life-threatening underlying diseases.
- Pregnant or lactating women.
- Positive for anti-HIV test.
- Mental disorders that may prevent the subject from completing the treatment or giving informed consent.
- The investigator deems the subject unsuitable for inclusion.
Key Trial Info
Start Date :
September 30 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2032
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06991920
Start Date
September 30 2025
End Date
April 1 2032
Last Update
May 28 2025
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