Status:
ACTIVE_NOT_RECRUITING
Trial of Pistachio Consumption in Older Adults
Lead Sponsor:
Brigham and Women's Hospital
Collaborating Sponsors:
American Pistachio Growers
Boston Children's Hospital, Boston, MA, USA
Conditions:
Cognition
Cardiometabolic Risk Factors
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
The goal of this study is to evaluate whether a pistachio-enriched diet leads to changes in cognitive function, cardiometabolic risk factors, and life satisfaction in older adults over a 6-month perio...
Detailed Description
In this remote-based, parallel-arm RCT, the investigators will recruit participants from the recently completed COcoa Supplement and Multivitamin Outcomes Study (COSMOS) trial cohort. Eligible COSMOS ...
Eligibility Criteria
Inclusion
- Active participant in COSMOS
- Current age 65 to 80 years
- Does not reside in the states of Arizona, Hawaii, or Wyoming (since Quest Diagnostics does not have locations in these states)
Exclusion
- Tree nut allergy
- Current intake of pistachios, peanuts, walnuts, or other nuts \>1 serving/week
- Diagnosis of Alzheimer's disease or any other type of dementia
- Diagnosis of cancer or CVD (MI, stroke, CABG, PTCA, or stent) within last 12 months
- Changes in the dose or number of anti-hypertensive, lipid-lowering, or diabetic medications over the past 3 months prior to randomization
- Does not own a smartphone or tablet
- Unable or unwilling to abstain from pistachio intake for 6 months
- Unable or unwilling to limit nut consumption to ≤1 serving/week for 6 months
- Unable or unwilling to complete online questionnaires and cognitive assessments
- Unable or unwilling to travel to a local Quest site for biospecimen collection
- Unable or unwilling to provide consent to participate in the trial
- Failure to complete the baseline Life Satisfaction Questionnaire
- Failure to complete the baseline cognitive assessments
- Failure to complete the baseline biospecimen collection
Key Trial Info
Start Date :
May 28 2025
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2026
Estimated Enrollment :
97 Patients enrolled
Trial Details
Trial ID
NCT06992544
Start Date
May 28 2025
End Date
June 1 2026
Last Update
September 23 2025
Active Locations (1)
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1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215