Status:
NOT_YET_RECRUITING
Heparin Binding Protein Versus Platelet Count and Mean Platelet Volume Kinetics in the Diagnosis and Prognosis of VAP
Lead Sponsor:
Esraa Hamdy Thabit Riad
Conditions:
Ventilator Associated Pneumonia (VAP)
Eligibility:
All Genders
18-70 years
Brief Summary
mechanically ventilated for 48 hours or more and subsequently develop ventilator-associated pneumonia (VAP). After obtaining approval from the local ethical committee at the Faculty of Medicine, El-Mi...
Detailed Description
This prospective, single-blinded observational study aims to investigate the prognostic value of heparin-binding protein (HBP), mean platelet volume (MPV) kinetics, and the MPV-to-platelet count (PC) ...
Eligibility Criteria
Inclusion
- 1\. Patients \< 18 years old\<70years 2. MV for more than 48 h. 3 . Signs of VAP according to clinical and radiological data , Modified Clinical Pulmonary Infection Score (CPIS) will be calculated for the patients and will be included when CPIS \> 6 . Modified CPIS will be calculated without considering culture results.(12)
Exclusion
- \- . Patients with pre-existing infections or sepsis at ICU admission. 2. Patients with underlying conditions such cancer, chronic liver illnesses, end-stage renal disease, etc. that may impact platelet function or morphology.
- 3\. primary hematological disorders, disseminated intravascular coagulation. 4.severe thrombocytopenia (platelet count ≤ 20x109 L-1) and receiving platelet transfusion.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2026
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT06993623
Start Date
September 1 2025
End Date
December 1 2026
Last Update
September 23 2025
Active Locations (1)
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1
Minia university Hospitals
Minya, Egypt