Status:
NOT_YET_RECRUITING
Substrates for Post-Stroke Arm Rehabilitation
Lead Sponsor:
Massachusetts General Hospital
Collaborating Sponsors:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Stroke Rehabilitation
Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Difficulty moving the arm is very common and a major cause of disability after stroke. Although rehabilitation therapies (i.e., occupational and physical therapy) are the most common treatments used t...
Detailed Description
Strokes commonly damage motor pathways in the brain which leads to "hemiparesis", the collective term given to the syndrome of motor dysfunction after stroke. Upper extremity hemiparesis is comprised ...
Eligibility Criteria
Inclusion
- first time unilateral ischemic or hemorrhagic stroke occurring within the 3-6 months
- upper extremity motor impairment as measured by the Upper Extremity Fugl-Meyer Assessment (UE-FMA) Score \<= 44
- ability to participate in a 6-week intensive upper extremity intervention in English as determined by a licensed occupational therapist.
Exclusion
- bilateral stroke
- unstable medical status affecting functional status
- pre-stroke upper extremity injury or conditions that limited use
- visual or auditory impairment limiting ability to participate in study procedures
- significant aphasia (NIHSS sub-item 9 \> 1) or cognitive (NIHSS 1a or 1b or
- 1c \> 1) deficits
- known or expected inability to maintain follow-up through the study intervention and post- assessment
- contraindications to MRI
- contraindications to TMS
- known history of uncontrolled seizure disorder.
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 30 2030
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT06998485
Start Date
September 1 2025
End Date
April 30 2030
Last Update
June 4 2025
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