Status:
COMPLETED
Cerebellar High-Frequency rTMS in Balance of Multiple Sclerosis Patients
Lead Sponsor:
Ain Shams University
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), leading to progressive motor dysfunction and balance deficits. Objective: To investigate...
Detailed Description
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), leading to progressive motor dysfunction and balance deficits. Although disease-modifyin...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patient age ≥18 years.
- Patients with MS, established by clinical, laboratory, MRI criteria and matched Mc Donald's criteria, McDonald et al, 2006.
- Expanded Disability Status Scale (EDSS) scores between 2.5-5
- Only patients in "remitting" phase were included.
- Informed consent.
- Exclusion criteria:
- Factors that prevent patient cooperation understanding that impede proper study participation.
- Disabling medical history as severe or recent heart disease and or severe head trauma.
- Cognitive impairment: \<24 points by mini-mental scale. (Folstein MF et al., 1975).
- Diabetic patients.
- Patients with any other comorbidity that can affect balance, e.g, other neurological diseases that can affect posterior column function.
- Contraindications for rTMS:
- History of epilepsy.
- Metal (implants) in skull/scalp/head or fragments from welding or metalwork.
- Implanted device (as spinal cord stimulator, cardiac pacemaker, and cochlear implants).
- Pregnancy.
Exclusion
Key Trial Info
Start Date :
February 25 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 25 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06998810
Start Date
February 25 2023
End Date
March 25 2025
Last Update
May 31 2025
Active Locations (1)
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1
Shereen Ismail Fawaz
Cairo, Other, Egypt, 11757