Status:
NOT_YET_RECRUITING
Quadriceps Motor Unit Adaptation to Simulated Knee Injury
Lead Sponsor:
University of Central Florida
Conditions:
Muscle Inhibition
Knee Injury Simulation
Eligibility:
All Genders
18-30 years
Phase:
NA
Brief Summary
This study investigates how simulated knee injury-via artificial joint effusion or deafferentation-affects quadriceps motor unit behavior in healthy young adults. Participants will complete neuromuscu...
Detailed Description
Using a controlled laboratory model, the investigators will simulate knee injury through two methods: (1) intra-articular saline injection to induce effusion, and (2) intra-articular lidocaine injecti...
Eligibility Criteria
Inclusion
- Age 18-30 years
- Physically active (Tegner ≥ 5)
- No prior lower-limb surgery or major injury
Exclusion
- Lower limb surgery or significant injury in past 2 years
- Cardiopulmonary, neurological, or psychiatric disorders
- Needle/electrical stimulation anxiety
- Medications affecting neuromuscular or psychological function
- Pregnancy
- Allergic to lidocaine
- Inability to elicit Hoffmann reflex
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT06999057
Start Date
August 1 2025
End Date
June 1 2026
Last Update
May 31 2025
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