Status:
RECRUITING
[68Ga]Ga-PSMA PET/CT in Hepatocellular Carcinoma: Impact of Multiparametric Dynamic Whole-body Imaging and Kinetic Modeling.
Lead Sponsor:
Nantes University Hospital
Conditions:
HCC - Hepatocellular Carcinoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the use of multiparametric dynamic whole-body \[68Ga\]Ga-PSMA PET/CT imaging in newly diagnosed HCC patients or in HCC patients with recent suspicion of refrac...
Eligibility Criteria
Inclusion
- Provided written informed consent
- Patient aged ≥ 18 years
- For cohort A: patient with HCC histologically proven or who meet radiological criteria and are scheduled for biopsy For cohort B: patient with known HCC requiring a new diagnostic imaging workup for suspected refractory, residual or recurrent disease
- Presence of at least one morphological evaluable lesion according to mRECIST 1.1 using contrast CT/MRI
- Patient must have an ECOG (Eastern Cooperative Oncology Group) performance status of 0 to 2
- Patient who are Child-Pugh A
- Patient must have a life expectancy ≥ 6 months as determined by the study investigator
- Patient affiliated to or beneficiary of the National Health Service
- Consent to practice double-barrier contraception after \[68Ga\]Ga-PSMA injection (6 months of contraception for women study participant and their partners, and 3 months for men study participant and their partners)
Exclusion
- Known hypersensitivity to PSMA-11, to any excipient or derivative or to radiographic contrast agents
- Patient requiring emergent surgery for a ruptured / bleeding HCC
- Radioembolization within 3 months prior to inclusion
- Cardiac disease with New York Heart Association classification of III or IV
- Any major surgery within 4 weeks before enrollment
- Other known malignancies (except for fully-resected non-melanoma skin cancer or cervical cancer in situ) unless definitively treated and proven no evidence of recurrence for 2 years
- Any uncontrolled significant medical, psychiatric or surgical condition (active infection (subjects with known human immunodeficiency virus (HIV) positive)), unstable angina pectoris, cardiac arrhythmia, poorly controlled hypertension, poorly controlled diabetes mellitus (glycated haemoglobin (HbA1c) ≥9%), uncontrolled congestive heart disease, etc.) or laboratory findings that, in the opinion of the investigator, might jeopardise the subject's safety or that would limit compliance with the objectives and assessments of the study
- Woman who are pregnant or breastfeeding. A serum pregnancy test will be performed at the start of the study for all female subjects of childbearing potential
- Patient under guardianship or trusteeship
- Patient under judicial protection
Key Trial Info
Start Date :
September 23 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 23 2027
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT06999837
Start Date
September 23 2025
End Date
September 23 2027
Last Update
October 7 2025
Active Locations (2)
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1
HU Paris Nord APHP
Clichy, France
2
CHU de Nantes
Nantes, France