Status:
RECRUITING
Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pilot Study
Lead Sponsor:
Washington University School of Medicine
Conditions:
Aging
Cognitive Decline
Eligibility:
All Genders
50-70 years
Phase:
PHASE2
Brief Summary
The purpose of this research study is to explore ways to improve motor, cognitive and immune functions for aging adults using multiple techniques like lifestyle changes and risk factor management, as ...
Detailed Description
The goal in this pilot open-label study is to conduct a feasibility test of a multi-component, personalized intervention designed to improve the aging human healthspan. The trial will recruit at least...
Eligibility Criteria
Inclusion
- Participants must be residents of Illinois or Missouri and able to come to St. Louis offices in person.
- Ages 50-70
- Able to come to the research center for testing and intervention visits.
- Sedentary (no moderate exercise and no more than 15-minutes per day of light exercise (confirmed via interview with participants)).
- BMI≥27 or Body Roundness index ≥6
- Able to provide informed consent.
Exclusion
- Dementia or other clinical neurodegenerative illness (e.g., Parkinson's disease, cerebrovascular disease unless minor eg one lacunar infarct with minimal/no impairment) per self-report or medical records.
- Medical conditions that suggest shortened lifespan (such as metastatic cancer), severe/uncontrolled psychiatric disorders or conditions that would prohibit safe participation.
- Unable to perform study assessments.
- Alcohol or substance abuse within 6 months per self-report or medical records.
- Concurrent cognitive training, such as brain-training software, or other interventions expected to affect neuroplasticity.
- Any drug that interacts pharmacokinetically, or is contraindicated with study interventions (examples would include high-dose SSRI that should not be combined with vortioxetine)
- PI has discretion to exclude potential participants eg if their health status appears either too good or too poor to be amenable to intervention
Key Trial Info
Start Date :
July 28 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT07000734
Start Date
July 28 2025
End Date
May 1 2026
Last Update
December 17 2025
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110