Status:
RECRUITING
Hypoxia Pathways for Early Recovery After Spinal Cord Injury
Lead Sponsor:
University of Florida
Collaborating Sponsors:
Brooks Rehabilitation
Conditions:
Spinal Cord Injuries (SCI)
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Spinal cord injury (SCI) disrupts neural pathways to respiratory motor neurons, diminishing breathing capacity and airway defense (e.g., cough). Indeed, respiratory impairment is a leading cause of in...
Detailed Description
The specific focus of this pilot study is to obtain preliminary data to inform a larger, more definitive clinical trial. The long-term objective of this line of work is to test the hypothesis that an ...
Eligibility Criteria
Inclusion
- Adults 18-70 years of age
- Sub-acute incomplete SCI 2 weeks to 6 months after injury, at or below C1-T6 Incomplete SCI based on residual sensory and motor function below the level of the injury or injury classification of B, C, D at initial screening according to the American Spinal Injury Association Impairment Classification and the International Standards for the Neurological Classification of SCI.
- OR- Sub-acute complete SCI 2 weeks to 6 months after injury at or below C4-T6 Complete SCI based on the absence of residual sensory or motor function below the level of injury or injury classification of A at initial screening according to the American Spinal Injury Association Impairment Classification and the International Standards for the Neurological Classification of SCI.
- Medically stable with physician clearance
- SCI due to non-progressive etiology
Exclusion
- Current diagnosis of an additional neurologic condition such as Multiple Sclerosis, Parkinson disease, stroke, or brain injury
- Severe illness or infection, including non-healing decubitus ulcers, untreated bladder or urinary tract infections, cardiovascular disease, lung disease, active heterotopic ossification, or uncontrolled hypertension
- Severe neuropathic pain
- Known pregnancy
- Severe uncontrolled autonomic dysreflexia
- Currently hospitalized in an acute care hospital
Key Trial Info
Start Date :
November 20 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2027
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT07002437
Start Date
November 20 2025
End Date
July 1 2027
Last Update
December 3 2025
Active Locations (1)
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1
Brooks Rehabilitation
Jacksonville, Florida, United States, 32216