Status:
NOT_YET_RECRUITING
Left Atrial Imaging Prior to Cardioversion: Leveraging Computed Tomography to Rule Out Thrombus in The Emergency Department (LA CLOTTED)
Lead Sponsor:
Ottawa Heart Institute Research Corporation
Conditions:
Atrial Fibrillation (AF)
Atrial Flutter
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this randomized clinical trial is to learn whether patients with symptomatic atrial fibrillation or atrial flutter (AF) who require heart imaging to rule out a blood clot before cardiovers...
Detailed Description
Atrial fibrillation and atrial flutter (AF) are the most common cardiac arrhythmias worldwide resulting in frequent visits to the emergency department (ED). Some patients can undergo chemical or elect...
Eligibility Criteria
Inclusion
- Age ≥18 years old; and
- Primary symptomatic AF without a reversible underlying cause (e.g. sepsis, pneumonia, pulmonary embolism, hyperthyroidism)
- LA imaging required before cardioversion according to local clinical practice guidelines
Exclusion
- Patients with an indication for emergency cardioversion (e.g. hemodynamic instability (systolic blood pressure\<90mmHg or signs of shock), cardiac ischemia (ongoing severe chest pain or marked ST depression on ECG \>2mm), or pulmonary edema (significant dyspnea, crackles, or hypoxia)); or
- Contraindication to CCT (renal insufficiency (eGFR\< 45ml/min/1.73m2), allergy to intravenous contrast agents, pregnancy (contraindications to radiation exposure), or inability to perform 20-second breath-hold)
Key Trial Info
Start Date :
June 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 15 2028
Estimated Enrollment :
190 Patients enrolled
Trial Details
Trial ID
NCT07002450
Start Date
June 15 2025
End Date
June 15 2028
Last Update
June 3 2025
Active Locations (1)
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1
The Ottawa Hospital Civic Campus
Ottawa, Ontario, Canada, K1Y 1J8