Status:
RECRUITING
Spatial Memory Training and Cognitive Function
Lead Sponsor:
Douglas Mental Health University Institute
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
Conditions:
Mild Cognitive Impairment
Eligibility:
All Genders
55+ years
Phase:
NA
Brief Summary
Mild cognitive impairment (MCI) is often considered a transitional stage between normal aging and dementia, particularly Alzheimer's disease (AD). Patients with MCI have subjective memory complaints c...
Detailed Description
The hippocampus (HPC) is a labile structure capable of neurogenesis and synaptic plasticity throughout the lifespan, which is thought to underlie its role in learning and memory, particularly of autob...
Eligibility Criteria
Inclusion
- Age 55 years and above.
- Primary language is English or French.
- Individuals having received a diagnosis of Mild Cognitive Impairment (MCI).
Exclusion
- Self-reported having either of the following:
- Current post-traumatic stress disorder and/or generalized anxiety disorder; Substance use disorder; Significant heart disease (i.e., stroke occurring during 5 years prior to study assessment or cardiac disease non-stabilized with medication); Severe Depression, or a Geriatric Depression Scale (GDS) score greater than 12; Current insomnia disorder.
- Current medications for sleep problems, or use of medications that affect sleep.
- Use of antidepressant and anti-anxiety medication for less than 3 months prior to study entry.
- Use of analgesics with codeine (or other opioids).
- Use of antipsychotic medication (past or current).
- Having undergone brain surgery or ECT.
- Self-reported colour-blindness.
- General anesthesia in the past year.
- Current smoker.
- Suspected or confirmed traumatic brain injury during the last 24 months.
- Motion sickness or intolerant to virtual reality tasks.
- Cholesterol or hypertension medication for less than 3 months or changes expected within the next 9 months.
- History or presence of neurological or psychiatric disorders (other than MCI) that in the opinion of the investigator may compromise patient safety or study objectives.
- Current severe medical conditions (e.g. untreated diabetes, cancer) that in the opinion of the investigator may compromise patient safety or study objectives.
- For female participants, severe menopausal symptoms, including hot flashes (determined from the Greene climacteric scale - any participants scoring over 15 is excluded).
- Use of computer games that are designed to help with memory or general cognition.
- Presence of any medical or psychological condition that, in the opinion of the principal investigator, may compromise the study objectives.
- Presence of contra-indications for MRI scanning.
Key Trial Info
Start Date :
June 15 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2030
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07002996
Start Date
June 15 2025
End Date
December 30 2030
Last Update
July 23 2025
Active Locations (1)
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1
Douglas Mental Health University Institute
Verdun, Quebec, Canada, H4G 3E8