Status:
NOT_YET_RECRUITING
A Cohort Study on Treating Primary Nocturnal Enuresis by Regulating Central-Peripheral Circadian Rhythm
Lead Sponsor:
Shanghai Children's Medical Center
Conditions:
Primary Nocturnal Enuresis
Eligibility:
All Genders
5-15 years
Phase:
NA
Brief Summary
Primary nocturnal enuresis (PNE), a prevalent pediatric disorder, suffers from therapeutic limitations characterized by low efficacy and high relapse rates. Targeting its core pathophysiology could si...
Detailed Description
The intervention training will last for 6 months. Researchers will compare the therapeutic efficacy of the "Circadian Rhythm Intervention Combined with Bladder Training Group (treatment group)" and th...
Eligibility Criteria
Inclusion
- Diagnosis according to the ICCS criteria:
- At least one episode of involuntary nighttime urination per month for more than 3 months.
- No abnormalities in routine urinalysis. No period of bedwetting-free days lasting more than 6 months, except for organic diseases.
- Age: 5 to 15 years (inclusive), regardless of gender.
- Right-handedness (as assessed by the Annett Hand Preference Questionnaire)
Exclusion
- Secondary nocturnal enuresis;
- History of head trauma, neurological disorders, psychosurgery, or major physical conditions (including autism spectrum disorder, epilepsy, cerebral palsy);
- Contraindications to fMRI.
- Note: Mild comorbidities commonly associated with primary nocturnal enuresis (e.g., ADHD) are permitted but must be included as covariates in statistical analyses.
Key Trial Info
Start Date :
July 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2028
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT07003126
Start Date
July 1 2025
End Date
June 1 2028
Last Update
June 4 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Shanghai children's medical center
Shanghai, Shanghai Municipality, China, 200127