Status:
NOT_YET_RECRUITING
Mecobalamin Combined With Anti-VEGF Intravitreal Injection for Retinal Vein Occlusion Treatment
Lead Sponsor:
First Affiliated Hospital of Chongqing Medical University
Conditions:
Retinal Vein Occlusion (RVO)
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
Retinal vein occlusion (RVO), a common retinal vascular disease, is frequently treated with anti-vascular endothelial growth factor (anti-VEGF) agents as first-line therapy. However, anti-VEGF monothe...
Detailed Description
Retinal vein occlusion (RVO) is the second leading cause of vision loss resulting from retinal vascular disease, with a prevalence of approximately 0.6%-1.6%. Macular edema (ME) secondary to RVO is a ...
Eligibility Criteria
Inclusion
- Diagnosis of RVO meeting the international diagnostic criteria 4,12, age 18-80 years, gender not limited Treatment-naive RVO-ME (no prior anti-VEGF, glucocorticoid, or laser therapy) The CFT is confirmed to be ≥300μm by OCT The baseline BCVA (ETDRS letter count) was 20/400 to 20/40 (34-78 letters) Signed informed consent and ability to comply with follow-up.
Exclusion
- Combined with other eye diseases that cause ME (such as diabetic retinopathy, uveitis) Media opacities affecting imaging (such as severe cataract, vitreous hemorrhage) Prior anti-VEGF, steroid, or macular laser therapy Systemic use of glucocorticoids or immunosuppressants within 3 months Uncontrolled systemic disease (hypertension, diabetes, hepatic/renal dysfunction); pregnant or lactating women Allergy to mecobalamin or conbercept Unable to cooperate with examinations or follow-up, or participate in other clinical trials within one year
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 31 2027
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07133438
Start Date
September 1 2025
End Date
July 31 2027
Last Update
August 21 2025
Active Locations (1)
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1
No. 1, Friendship Road, Yuanjiagang, Yuzhong District, Chongqing City
Chongqing, China, 400016