Status:
NOT_YET_RECRUITING
Multimodal Imaging Evaluation of Vulnerability of Atherosclerotic Plaques: A Comparison of HR-VWI, OCT, and RWS
Lead Sponsor:
Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Conditions:
Intracranial Atherosclerotic Stenosis
Eligibility:
All Genders
18+ years
Brief Summary
The primary objective of this study is to evaluate the vulnerability of intracranial and extracranial atherosclerotic plaques using HR-VWI, OCT, and RWS technologies, while exploring correlations amon...
Detailed Description
Intracranial atherosclerotic stenosis (ICAS) is one of the leading causes of ischemic cerebrovascular disease worldwide, with an incidence rate as high as 46.6% among ischemic stroke or transient isch...
Eligibility Criteria
Inclusion
- At least 18 years old;
- Severe stenosis of intracranial arteries (stenosis degree: 70% \~ 99%, traditional angiography is required to confirm the degree of stenosis according to the criteria of Warfarin-Aspirin Symptomatic Intracranial Disease (WASID) study);
- Carry out cerebral angiography and OCT within one week after HR-VWI examination;
- The patient or the legal representative of the patient is able and willing to sign an informed consent form.
Exclusion
- Non-atherosclerotic intracranial and extracranial artery stenosis, such as dissection, smoke disease, etc.;
- There are contraindications to MRI, such as claustrophobia, metal implants, etc.; Renal insufficiency, elevated serum creatinine (more than twice the upper limit of normal);
- Patients with severe cardiopulmonary diseases were considered unsuitable for this study;
- Allergy to iodine or gadolinium contrast agent;
- Participants who were unable to complete the study due to mental illness, cognitive or emotional disorder.
Key Trial Info
Start Date :
August 10 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2030
Estimated Enrollment :
561 Patients enrolled
Trial Details
Trial ID
NCT07133451
Start Date
August 10 2025
End Date
June 30 2030
Last Update
August 21 2025
Active Locations (1)
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1
Shanghai 6th People's Hospital
Shanghai, China, 200023