Status:
NOT_YET_RECRUITING
QL1706/Bevacizumab ± Chemotherapy in Post-ICI Non-Squamous NSCLC
Lead Sponsor:
Guangdong Association of Clinical Trials
Conditions:
NSCLC
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The goal of this clinical trial is to evaluate QL1706 plus bevacizumab with or without chemotherapy in patients with PD-L1-negative, locally advanced or metastatic non-squamous non-small cell lung can...
Eligibility Criteria
Inclusion
- Signed an informed consent form
- Patients aged ≥18
- Histologically or cytologically confirmed stage III or IV non-squamous non-small cell lung cancer (NSCLC) per the American Joint Committee on Cancer (AJCC) 8th Edition staging system
- at least one measurable lesion according to RECIST 1.1 criteria
- ECOG PS 0-1.
- Subjects must have adequately documented disease progression following prior treatment with PD-1/PD-L1 inhibitors (administered as monotherapy or in combination with chemotherapy)
- 8\. The most recent tumor tissue sample prior to the first dose of the study drug demonstrated PD-L1 TPS \<1% 9. appropriate organ function
Exclusion
- Known presence of sensitizing mutations in EGFR, EGFR exon 20 insertions, ALK fusions, ROS1 fusions, RET fusions, NTRK fusions, BRAF V600E mutations, MET exon 14 skipping mutations, or HER2 sensitizing mutations (for other genetic alterations, eligibility will be determined by the Biomarker Committee on a case-by-case basis).
- Patients with symptomatic, neurologically unstable central nervous system (CNS) metastases, or CNS diseases that require increased steroid doses to control
- Prior lines of systemic anti-tumor therapy ≥ 2.
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2029
Estimated Enrollment :
77 Patients enrolled
Trial Details
Trial ID
NCT07134413
Start Date
August 1 2025
End Date
July 1 2029
Last Update
August 21 2025
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