Status:
NOT_YET_RECRUITING
Thoracic Surgery Intercostal Block Trial With Liposomal vs. Hydrochloride Bupivacaine
Lead Sponsor:
Shanghai Pulmonary Hospital, Shanghai, China
Conditions:
Postoperative Pain, Acute
Lung Cancer
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This randomized controlled trial evaluates the analgesic effects of liposomal bupivacaine compared to bupivacaine hydrochloride in intercostal nerve block for patients undergoing thoracoscopic lung su...
Detailed Description
Background: Lung cancer surgery, even with minimally invasive thoracoscopy, causes significant postoperative pain in up to 62.9% of patients, potentially leading to complications and chronic pain. Int...
Eligibility Criteria
Inclusion
- Scheduled for elective unilateral thoracoscopic (VATS) lung surgery
- Age 18 to 80 years
- American Society of Anesthesiologists (ASA) physical status I-III
Exclusion
- Contraindication to local anesthetics (infection at puncture site, allergy to local anesthetics, coagulopathy or other bleeding risk)
- Sensory abnormalities in the planned chest-wall surgical area
- Hepatic dysfunction (ALT \> 50 U/L, AST \> 40 U/L, or total bilirubin ≥ 19 μmol/L) or renal dysfunction (serum creatinine \> 112 μmol/L, BUN \> 7.1 mmol/L, or dialysis within 28 days before surgery)
- Pregnancy, breastfeeding, women of childbearing potential not using adequate contraception, or planning pregnancy during the study period
- Preoperative opioid use, history of chronic pain, or history of opioid abuse
- Refusal to provide informed consent
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 20 2025
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT07134660
Start Date
September 1 2025
End Date
December 20 2025
Last Update
September 5 2025
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.