Status:
RECRUITING
Immune Dynamics in the Natural History of Chronic HBV Infection
Lead Sponsor:
Nanfang Hospital, Southern Medical University
Conditions:
HBV (Hepatitis B Virus)
HBV Infection
Eligibility:
All Genders
1-80 years
Brief Summary
The purpose of this observational study is to follow up on chronic HBV-infected patients over a long period of time to understand the changes in the immune status as age increases and the natural hist...
Detailed Description
Research Objectives This study aims to investigate the mechanisms underlying the changes and potential deficiencies in humoral and cellular immunity caused by chronic HBV infection through the analysi...
Eligibility Criteria
Inclusion
- Aged 1-80 years, either male or female.
- Patients diagnosed with chronic hepatitis B virus infection in accordance with the "Guidelines for the Prevention and Treatment of Chronic Hepatitis B" (2019 edition).
- No antiviral treatment (including nucleoside analogs and interferons, etc.) within the past six months.
Exclusion
- • Concurrent Infections and Liver Diseases: Exclusion of patients with concurrent HCV or HIV infection, alcoholic fatty liver disease, non-alcoholic fatty liver disease, autoimmune liver diseases.
- • Immune and Coagulation System Disorders: Exclusion of patients with immune system diseases such as hyperthyroidism, coagulation system disorders such as diabetes mellitus or idiopathic thrombocytopenic purpura.
- Severe Underlying Diseases. Exclusion of patients with severe underlying diseases that affect the body's immune status.
- Other Unsuitable Conditions:
- Exclusion of patients whom the investigator deems to have other conditions that make them unsuitable for enrollment.
Key Trial Info
Start Date :
February 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2041
Estimated Enrollment :
5000 Patients enrolled
Trial Details
Trial ID
NCT07137247
Start Date
February 1 2024
End Date
December 1 2041
Last Update
September 30 2025
Active Locations (1)
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1
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515