Status:

ACTIVE_NOT_RECRUITING

Fundus-first Laparoscopic Cholecystectomy

Lead Sponsor:

Minia University

Conditions:

Cholecystitis

Acute Cholecystitis

Eligibility:

All Genders

18-80 years

Phase:

NA

Brief Summary

Bile duct injury (BDI) remains the most feared complication of laparoscopic cholecystectomy, particularly in difficult gallbladder cases. The fundus-first technique has emerged as a potentially safer ...

Detailed Description

Bile duct injury (BDI) rates remain 0.3-1.5% in difficult gallbladders. FFLC avoids early dissection near critical structures, potentially lowering BDI risk. This randomized controlled trial aims to ...

Eligibility Criteria

Inclusion

  • Age 18-80 years
  • Symptomatic cholelithiasis or cholecystitis requiring laparoscopic cholecystectomy (elective or emergency)
  • Difficult gallbladder characteristics: Acute cholecystitis (Tokyo Guidelines 2018 Grade II/III), wall thickness \>4 mm on US, pericholecystic fluid, impacted stone in Hartmann's pouch/cystic duct, previous upper abdominal surgery, BMI \>30 kg/m², ≥3 previous cholecystitis episodes, contracted gallbladder, Mirizzi syndrome Type I/II, empyema, severe pericholecystic adhesions on imaging, suspected anatomical variations
  • The American Society of Anesthesiologists (ASA) physical status I-III
  • Suitable for laparoscopic approach
  • Informed consent

Exclusion

  • Suspected gallbladder malignancy
  • Choledocholithiasis requiring endoscopic intervention
  • Mirizzi syndrome Grade III-IV
  • Gallbladder perforation with generalized peritonitis
  • Pregnancy or lactation
  • Contraindications to laparoscopy (severe cardiopulmonary disease, coagulopathy)
  • Previous biliary or hepatic surgery
  • Cirrhosis with portal hypertension
  • Active coagulopathy
  • Patient refusal

Key Trial Info

Start Date :

May 1 2024

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

January 1 2026

Estimated Enrollment :

174 Patients enrolled

Trial Details

Trial ID

NCT07137546

Start Date

May 1 2024

End Date

January 1 2026

Last Update

December 5 2025

Active Locations (1)

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1

Liver and GIT hospital / Minia university

Minya, Minya Governorate, Egypt, 61519