Status:
NOT_YET_RECRUITING
Screening of Predictive Biomarkers for Cardiorenal Syndrome
Lead Sponsor:
Haiyan Pan
Conditions:
Cardiorenal Syndrome (CRS)
Eligibility:
All Genders
18-75 years
Brief Summary
This study aims to explore the predictive value of specific biomarkers for cardiorenal syndrome (CRS) in patients with chronic heart failure (CHF). Building on previous research using Luminex technol...
Detailed Description
This study is a prospective observational cohort study designed to screen and validate the predictive value of five serum biomarkers (secretory leukocyte protease inhibitor \[SLPI\], Serpin E1, C-X-C ...
Eligibility Criteria
Inclusion
- Adults aged 18 to 75 years.
- Diagnosed with stable chronic heart failure (HF) according to the 2024 Chinese Heart Failure Diagnosis and Treatment Guideline.
- HF subtypes include:
- HFrEF (LVEF ≤40%), HFmrEF (LVEF 41 - 49%), HFpEF (LVEF ≥50%).
- Willing to provide blood samples for biomarker analysis.
- Able to comply with follow - up visits and study procedures for 12 months.
- Note: For the screening phase, 10 patients will be included for each subtype; for the validation phase, 30 patients will be included for each subtype.
Exclusion
- History of long-term dialysis or kidney surgery.
- Acute kidney injury (AKI) within the past 3 months.
- Use of nephrotoxic drugs within the past 3 months.
- Diagnosis of autoimmune diseases (e.g., lupus, rheumatoid arthritis).
- Active malignancy or history of cancer treatment within the past 5 years.
- Acute infectious diseases at the time of enrollment.
- Severe liver dysfunction (e.g., cirrhosis, ALT/AST \>3× upper limit of normal).
- Pregnancy or lactation.
- Inability or unwillingness to provide informed consent.
- Participation in another interventional clinical trial within the past 30 days.
Key Trial Info
Start Date :
September 15 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2027
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT07139626
Start Date
September 15 2025
End Date
December 31 2027
Last Update
September 8 2025
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