Status:
RECRUITING
rTMS for Youth Inpatients With Depression
Lead Sponsor:
Sunnybrook Health Sciences Centre
Conditions:
Major Depression Moderate
Feasibility Studies
Eligibility:
All Genders
14-19 years
Phase:
NA
Brief Summary
Youth aged 15-24 are likelier to have depression than all age groups in Canada. One-third of depressed youth do not respond to psychotherapy and/or antidepressant medications. A treatment called repet...
Eligibility Criteria
Inclusion
- age 14-19 years
- primary diagnosis of major depressive disorder or of bipolar I or II disorder, current episode depressed with no psychotic or mixed features
- current episode of depression lasting at least 4 weeks
- failed ≥1 evidence-based psychotherapy or antidepressant
- have a GRID-HAMD-17 (17-item Hamilton Depression Rating Scale) score of ≥16 (moderate-severe range)
- currently an inpatient or suitable for an elective inpatient admission
Exclusion
- lifetime diagnosis of a psychotic disorder, anorexia nervosa, bulimia nervosa diagnosis of a substance use disorder (except caffeine and tobacco) within the past year
- obsessive compulsive disorder or personality disorder that is the main source and driver of distress
- active psychosis and/or mania
- history of epilepsy or any other neurologic condition that includes a history of seizures
- use of medications that lower the seizure threshold
- pregnancy or nursing
- history of severe headaches within the previous year
- improvement in depressive symptom severity between screening and baseline by 25% or more
- inability to adhere to the protocol
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07140575
Start Date
August 1 2025
End Date
December 1 2027
Last Update
August 24 2025
Active Locations (1)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5