Status:
NOT_YET_RECRUITING
Randomized Trial of Erector Spinae Plane Block Using Liposomal Bupivacaine Versus Bupivacaine Hydrochloride on Quality of Recovery for Video-assisted Thoracic Surgery
Lead Sponsor:
RenJi Hospital
Conditions:
Regional Anesthesia Morbidity
Pain, Postoperative
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Video-assisted thoracoscopic surgery (VATS) has emerged as the standard surgical modality for pulmonary tumor. Compared with open thoracotomy, VATS is associated with reduced surgical trauma, attenuat...
Detailed Description
This is a prospective randomized controlled trial. Patients scheduled for elective video-assisted thoracoscopic pulmonary resection will be randomly assigned to two groups: the liposomal bupivacaine g...
Eligibility Criteria
Inclusion
- 18-75 yr of age
- ASA physical status 1 to 3
- Undergoing unilateral lung VATS under general anesthesia
- Obtaining informed consent from patients or legal representative
Exclusion
- Unexpected convention of VATS to open thoracotomy,or unexpected post-operative admission to ICU for continued ventilation
- Unable to understand the Quality of Recovery-15 (QoR-15) and Numerical Rating Scale(NRS)
- Allergy to or contraindications for amide local anesthetics,opioids,or NSAIDs
- Long-term treatment with opioids or corticosteroids (\>2 weeks)
- Drug use or substance abuse within the past 2 years
- Consuming more than 3 standard drinks per day (10g of alcohol,equivalent to 50g of Chinese high-alcohol liquor)
- Pre existing dementia that may interfere with perioperative assessment
- Contraindications for nerve block,including infection or tumor at the puncture site,definitively diagnosed diabetic peripheral neuropathy
- Suffering from severe hepatic insufficiency (Child-Pugh C),or severe renal insufficiency with dialysis,or severe heart failure (METS\<4)
- Pregnant or lactating women
- Previous thoracic surgeries (such an thoracic surgery or breast surgery),or preoperatively pathological pain conditions (e.g.,metastatic tumors,herpes zoster,etc)
Key Trial Info
Start Date :
August 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2028
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT07141667
Start Date
August 1 2025
End Date
March 1 2028
Last Update
August 26 2025
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