Status:
RECRUITING
Salivary E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 Levels in Recurrent Aphthous Stomatitis
Lead Sponsor:
Selin Yeşiltepe
Collaborating Sponsors:
Aydın Adnan Menderes University Scientific Research Projects Unit
Aydin Adnan Menderes University
Conditions:
Recurrent Aphthous Stomatitis
Aphthous Ulcer
Eligibility:
All Genders
18+ years
Brief Summary
The goal of this observational cross-sectional study is to determine the salivary levels of E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 (MMP-9) in patients with Recurrent Aphthous Stomati...
Detailed Description
Hypotheses H₀ (Null Hypothesis): There is no statistically significant difference in salivary levels of E-cadherin, Calprotectin, and Matrix Metalloproteinase-9 (MMP-9) between patients with Recurrent...
Eligibility Criteria
Inclusion
- Participants aged 18 years or older
- Clinically diagnosed with minor recurrent aphthous stomatitis (RAS) (defined as having a history of at least three RAS episodes within the past year)
- Systemically healthy (i.e., without any diagnosed systemic disease)
- No history of tobacco use
- Presence of at least one active aphthous ulcer at the time of saliva sample collection
- No known mental or physical disabilities
Exclusion
- Use of any pharmacological treatment within the past 3 months
- Use of antiseptic mouthwash within the past 3 months
- Pregnant or lactating individuals, or those currently using oral contraceptives
- History of systemic diseases associated with oral ulcerations such as Crohn's disease, ulcerative colitis, celiac disease, or Behçet's disease
- History of chemotherapy or radiotherapy
- Current or prior use of immunomodulatory drugs, cytotoxic agents, or systemic corticosteroids
- Undergoing orthodontic treatment (to avoid misdiagnosis with traumatic ulcers)
- Use of removable dental prostheses (to avoid misdiagnosis with traumatic ulcers)
- Presence of periodontal disease (CPI score of 3 or 4)
- Caries risk not classified as very low (DMFT ≥ 5)
- Presence of pathological oral mucosal lesions such as lichen planus, pemphigus vulgaris, or mucous membrane pemphigoid
Key Trial Info
Start Date :
April 10 2025
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT07141758
Start Date
April 10 2025
End Date
June 30 2026
Last Update
August 26 2025
Active Locations (1)
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1
Aydın Adnan Menderes University
Aydin, Efeler, Turkey (Türkiye), 09010