Status:
ACTIVE_NOT_RECRUITING
Impact of General Anesthesia in Childhood on Cognitive Processes
Lead Sponsor:
University Hospital, Caen
Conditions:
Neurodevelopmental Disorders
Child Behavior Disorders
Eligibility:
All Genders
8-10 years
Brief Summary
This study aims to evaluate the potential long-term cognitive effects of general anesthesia administered before the age of 4. Specifically, it investigates executive functions-including inhibition, wo...
Detailed Description
This study investigates the long-term cognitive effects of early exposure to general anesthesia in children. Specifically, it focuses on evaluating executive functions-namely inhibition, working memor...
Eligibility Criteria
Inclusion
- Children aged 9-10 years Mainstream class (non-specialized) Requirement for information on the right to object Requirement for affiliation with social security French-speaking
Exclusion
- Criteria for "Parents" Parental refusal Twins Exposure to general anesthesia during pregnancy, including cesarean section under general anesthesia
- Pregnancy-related pathology:
- Pregnancy-induced hypertension
- Preeclampsia
- Gestational diabetes
- Threat of preterm labor
- Depressive syndrome
- Chronic treatment during pregnancy:
- Pregnancy-induced hypertension: antihypertensive treatment (beta-blockers, calcium channel blockers)
- Preeclampsia: antihypertensive treatment (beta-blockers, calcium channel blockers), magnesium sulfate
- Gestational diabetes: dietary regimen, insulin
- Threat of preterm labor: prenatal corticosteroid therapy, magnesium sulfate
- Depressive syndrome: antidepressant psychotropic treatment Smoking during pregnancy, alcohol consumption during pregnancy, drug use during pregnancy Criteria for "Children" Child refusal to participate in the study Premature birth (i.e., before 37 weeks of gestation) Evolving or chronic psychiatric pathology, whether or not requiring chronic treatment Evolving or chronic neurological or neuromuscular pathology Genetic pathology Any chronic pathology requiring specialized follow-up and/or treatment (doctor, psychologist, speech therapist) Specialized neuro-pediatric or pediatric psychiatric follow-up, or follow-up with a psychologist or speech therapist during childhood Neuro-visual disorders (excluding normal vision with correction) Hearing disorders, whether or not using hearing aids Chronic otorhinolaryngological pathology, including sleep apnea syndrome, with or without apparatus Developmental disorders: ADHD, autism, or other, whether or not requiring chronic treatment Pediatric intensive care hospitalization Conventional hospitalization for more than 1 week during childhood Child who underwent multiple general anesthesias before the age of 4
Key Trial Info
Start Date :
October 1 2024
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2025
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT07141797
Start Date
October 1 2024
End Date
September 1 2025
Last Update
August 26 2025
Active Locations (1)
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1
University Hospital Caen Normandie
Caen, Normandy, France, 14000