Status:
NOT_YET_RECRUITING
Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression
Lead Sponsor:
Medipol University
Conditions:
Periodontal Diseases
Inflammation
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Ribonucleic acids (RNA) are molecules that transfer genetic information from the nucleus to the cytoplasm for protein translation. A subgroup of non-coding or non-messenger RNAs, known as microRNAs (m...
Detailed Description
Healthy participants (n:25) enrolled for this study. Samples will be collected for each patient at the following time points: immediately before the initiation of retinoic acid treatment, during treat...
Eligibility Criteria
Inclusion
- systemically healthy
- over 18 and under 45 years of age
- have at least 20 natural permanent teeth in occlusion excluding third molars,
- not be pregnant,
- have not used any antimicrobial and/or anti-inflammatory drugs in the past 3 months,
- have not received periodontal treatment in the past 6 months,
- have not undergone surgical periodontal treatment within the past year.
Exclusion
- history of regular use of systemic antibiotics anti-inflammatory, or antioxidant drugs (previous 3 months)
- nonsurgical periodontal treatment (previous 6 months)
- surgical periodontal treatment (previous 12 months)
- current medications affecting gingival health (calcium channel blockers, phenytoin, cyclosporine, and hormone replacement therapy)
- pregnancy
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2026
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT07142070
Start Date
September 1 2025
End Date
February 1 2026
Last Update
August 26 2025
Active Locations (1)
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1
Istanbul Medipol University, School of Dentistry
Istanbul, Fatih, Turkey (Türkiye)