Status:
RECRUITING
Determination of Iron Absorption and Losses in People Living at High Altitude to Investigate the Requirements in This Population Group Using a Newly Developed Technique
Lead Sponsor:
Diego Moretti
Collaborating Sponsors:
Swiss Federal Institute of Technology
University of Lausanne
Conditions:
Iron Absorption
Iron Requirements
Eligibility:
All Genders
18-45 years
Phase:
NA
Brief Summary
Iron is an essential micronutrient responsible for a whealth of biological processes of the human body. Iron plays a fundamental role especially in oxygen transport, by binding to hemoglobin in the bl...
Detailed Description
This study compares iron absorption in two population groups residing at different altitudes in Switzerland-one below 1000 meters above sea level and the other above 1500 meters. Additionally, the stu...
Eligibility Criteria
Inclusion
- Females and males aged 18-45 y
- BMI: 18 to 25 kg/m2
- Body weight \<70 kg for females, \<80 kg for males
- Plasma ferritin \>25 µg/L
- Signed informed consent
Exclusion
- Hb \<12 g/dL (females), Hb \<13 g/dL (males), corrected for altitude using the 2024 WHO guidance values for hemoglobin adjustments
- Inflammation (CRP \> 5 mg/L)1
- Plasma ferritin \>150 µg/L for females and \>200 µg/L for males
- Chronic disease known to affect iron metabolism
- Chronic medications (except for oral contraceptives)
- Pregnancy (tested at screening) or intention to become pregnant during the course of the study
- Lactation
- High physical activity (MET-min/week \> 3000 calculated according to the IPAQ, short version, administered at the screening)
- Difficulty with blood withdrawal
- Earlier participation in a study using stable iron isotopes or participation in any clinical study within the last 30 days
- Smoking
- Blood donation, blood transfusion or significant blood loss (more than 400 mL) over the past 6 months
- Intention to regularly donate blood during the 2 years duration of the study
- No residence in the respective location/altitude for at least the last 2 years
- No intention to reside in the respective location/altitude at least for the next 2 years
- Participants who are planning to spend an extended period (\>12 weeks) at a different altitude from their residence location
- Spending more than 2 nights per week at a different location from residence location
- Inability to understand the information sheet and the informed consent form due to cognitive or language reasons
Key Trial Info
Start Date :
August 22 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2028
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT07142590
Start Date
August 22 2025
End Date
February 1 2028
Last Update
November 20 2025
Active Locations (1)
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1
Fernfachhochschule Schweiz (FFHS)
Zurich, Canton of Zurich, Switzerland, 8005