Status:
RECRUITING
Transcranial Pulse Stimulation for Alzheimer's Disease
Lead Sponsor:
Chinese University of Hong Kong
Collaborating Sponsors:
Asia Pacific Institute of Healthy ageing
Associated medical supplies company limited
Conditions:
Alzheimer Dementia (AD)
Eligibility:
All Genders
60-90 years
Phase:
PHASE2
Brief Summary
TPS is a non-invasive therapeutic modality that uses focused, low-energy pulse stimulation to stimulate tissue regeneration and reduce inflammation. In the context of neurological disorders, it is hyp...
Detailed Description
This pilot randomized placebo-controlled trial investigates the effects of transcranial pulse stimulation in subjects with early Alzheimer's Disease (AD). The TPS/Sham-TPS is administered for the firs...
Eligibility Criteria
Inclusion
- Adults who have been clinically diagnosed with Alzheimer's Disease in the early stage 2-6a according to the Functional Assessment Staging Test (In Appendix A)
- The mental capacity to give informed consent for research is made by an experienced geriatrician based on Appendix A.
- Aged 60-90 years old.
- Able to make informed consent under assistance, which is witnessed and signed by a family caregiver.
Exclusion
- Cannot understand Chinese.
- Mentally incapacitated, unable to provide informed consent
- Inability to remain still for 30 minutes
- Lack of available family caregiver to answer questionnaires
- Alcohol or substance dependence
- Major neurological conditions, including:
- Brain tumor
- Brain aneurysm
- Presence of any metal implants in the brain
- Hemophilia or other blood clotting disorders
- History of thrombosis
Key Trial Info
Start Date :
July 21 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT07143734
Start Date
July 21 2025
End Date
June 1 2026
Last Update
September 16 2025
Active Locations (1)
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1
Department of Medicine & Therapeutics, Faculty of Medicine, The Chinese UNiversity of Hong Kong
Hong Kong, Hong Kong