Status:
NOT_YET_RECRUITING
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Pain, Acute
Pain, Chronic
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and b...
Detailed Description
INTRODUCTION Managing pain after cardiac surgery is a complex challenge. Traditional pain medications like opioids and NSAIDs are effective but come with significant side effects, including addiction...
Eligibility Criteria
Inclusion
- Adult patients aged 18 or older
- elective surgery
- coronary artery bypass graft (CABG), valve repair/replacement, combined CABG/valve procedure, or major aortic procedure via sternotomy
Exclusion
- emergency surgery
- redo surgery
- history of chronic pain or on chronic opioids/sedatives
- already taking taurine or butyrate prior to enrolment
- renal failure with estimated glomerular filtration rate \<30mL/min (calculated by Cockcroft-Gault formula)
- re-operation within 24 hours after surgery
- intraoperative use of remifentanil
- inability to provide informed consent.
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 31 2028
Estimated Enrollment :
216 Patients enrolled
Trial Details
Trial ID
NCT07144033
Start Date
January 1 2026
End Date
January 31 2028
Last Update
September 5 2025
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong