Status:
NOT_YET_RECRUITING
Prevalence of Alpha-1 Antitrypsin Deficiency in Non-Cirrhotic Liver Cancer
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Retrospective Cohort of Patients Diagnosed With HCC on Non-Cirrhotic Liver
Eligibility:
All Genders
18+ years
Brief Summary
Patients with Alpha-1 Antitrypsin Deficiency (AATD), a rare genetic disease, have a 20- to 50-fold higher risk of developing primary liver cancer (PLC), such as hepatocellular carcinoma (HCC), in both...
Detailed Description
The two most common pathogenic AATD variants, PiS and PiZ, will be identified using the multiplex digital PCR (dPCR) system in a French cohort of 71 patients who developed HCC in a non-cirrhotic liver...
Eligibility Criteria
Inclusion
- Adult patients (≥18 years of age).
- Histopathologically confirmed diagnosis of hepatocellular carcinoma (HCC).
- Normal liver or chronic liver disease with minimal to moderate fibrosis in non-tumoral tissue.
- Signed informed consent obtained prior to participation.
- No other known etiology or risk factors for liver disease, including:
- Alcohol-related liver disease
- Metabolic-associated steatohepatitis (MASH)
- Viral hepatitis infections
- Hemochromatosis
Exclusion
- Minor patients (\<18 years of age).
- HCC diagnosis not established according to standard histopathological criteria.
- Liver with chronic liver disease showing advanced fibrosis in non-tumoral tissue.
- No signed informed consent prior to participation.
- Presence of other identified etiologies or known risk factors for liver disease, including:
- Alcohol-related liver disease
- Metabolic-associated steatohepatitis (MASH)
- Viral hepatitis infections
- Hemochromatosi
Key Trial Info
Start Date :
January 1 2026
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
71 Patients enrolled
Trial Details
Trial ID
NCT07145385
Start Date
January 1 2026
End Date
September 1 2027
Last Update
January 5 2026
Active Locations (1)
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1
CHU Bordeaux
Bordeaux, France