Status:
RECRUITING
The Electroencephalographic Mechanisms of Anesthesia and Human Consciousness
Lead Sponsor:
Guangzhou General Hospital of Guangzhou Military Command
Conditions:
Consciousness, Level Altered
Eligibility:
All Genders
3-65 years
Phase:
PHASE4
Brief Summary
In the field of general anesthesia research, the neural mechanism underlying the loss of consciousness has long been a highly core issue. It remains unclear what consciousness is and how it emerges fr...
Eligibility Criteria
Inclusion
- Age range: 1 - 65 years old
- BMI: 18.5 - 25.0 kg/m²
- ASA physical status classification: I - III
- Patients diagnosed with drug - refractory epilepsy who, after long - term monitoring of epileptic seizures, require stereo-electroencephalography (SEEG) electrode implantation based on the clinical need for monitoring their epilepsy.
- Patients voluntarily participate in this study and sign a written informed consent form.
Exclusion
- Patients with severe arrhythmia or other organic heart diseases;
- Patients with comorbid obstructive sleep apnea-hypopnea syndrome (OSAHS);
- Patients with hepatic or renal dysfunction; those with a history of immunodeficiency diseases , or a history of cancer/malignant tumors, or a history of autoimmune diseases, or severe cardiovascular and cerebrovascular diseases, or other diseases that may significantly reduce life expectancy;
- Patients with any history of diseases that may affect protocol compliance (such as severe mental disorders, disturbance of consciousness; cognitive dysfunction, drug abuse or addiction, etc.);
- Pregnant or lactating women, or those of childbearing potential who are unwilling/unable to take effective contraceptive measures;
- Patients with known allergies to the ingredients contained in the drugs used in this study;
- Patients who have participated in any drug clinical trial within 6 months before the screening examination;
- Patients who are deemed unsuitable to participate in this study by the researcher.
Key Trial Info
Start Date :
April 10 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2027
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT07145697
Start Date
April 10 2025
End Date
June 30 2027
Last Update
August 28 2025
Active Locations (1)
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1
General hospital of southern theater command, PLA
Guangzhou, Guangdong, China, 510000