Status:
RECRUITING
Moxidectin Versus Ivermectin as Mass Drug Administration for the Control of Onchocerciasis and Other Neglected Tropical Diseases
Lead Sponsor:
Kirby Institute
Collaborating Sponsors:
Emory University
La Trobe University
Conditions:
Onchocerciasis
Ascaris Lumbricoides Infection
Eligibility:
All Genders
5+ years
Phase:
PHASE4
Brief Summary
This clinical trial compares two treatments - ivermectin and moxidectin - to learn which is better at reducing the proportion of people with onchocerciasis (river blindness) when given through mass dr...
Eligibility Criteria
Inclusion
- Male or female children and adults
- Residents in the villages selected for MDA treatment
Exclusion
- Arm 1 (ivermectin): children under the age of 5 and/or under 90 cm of height
- Arm 2 (moxidectin): children under the age of 12 years (who will receive ivermectin if they are at least 90 cm in height/5 years of age and above).
- Arm 1 (ivermectin): Women breast-feeding babies under 45 days of age
- Arm 2 (moxidectin): All breastfeeding women (who will be offered ivermectin if their infants is at least 45 days old)
- Know allergy to ivermectin or moxidectin
- Attending other clinical trials during the study
- Pregnant
- Arm 2 (moxidectin): Women planning to become pregnant in the 3 months post-treatment
- Refusal to receive one or both study drugs, i.e. participants in villages allocated to receive moxidectin who refuse to receive moxidectin will be given the option to receive ivermectin; if they refuse to receive both drugs they will be excluded from the MDA altogether
- Has an illness that makes them too sick or weak to get out of bed
- Currently hospitalized
Key Trial Info
Start Date :
August 4 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2029
Estimated Enrollment :
52000 Patients enrolled
Trial Details
Trial ID
NCT07145736
Start Date
August 4 2025
End Date
June 30 2029
Last Update
November 21 2025
Active Locations (1)
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1
Villages in Andulo and Nharea Municipalities
Andulo, Bíe Province, Angola