Status:
RECRUITING
Evaluation of Self-assembling Peptides Versus Amorphous Calcium Phosphate in the Treatment of White Spot Lesions
Lead Sponsor:
Ain Shams University
Conditions:
Dental Caries Tooth Demineralization
Post-Orthodontic Esthetic Defects
Eligibility:
All Genders
15-25 years
Phase:
NA
Brief Summary
This clinical trial aims to compare the effectiveness of two remineralizing treatments for white spot lesions (WSLs) on the enamel surfaces of the front teeth. WSLs are early signs of tooth decay, oft...
Detailed Description
White spot lesions (WSLs) are early signs of tooth decay that appear as milky white spots on tooth enamel, especially common after wearing braces. These lesions can last for many years and negatively ...
Eligibility Criteria
Inclusion
- Age between 15 and 25 years
- Presence of at least one tooth on each side of the anterior region (from right canine to left canine) affected by early carious lesions (ICDAS II code 1 or 2)
- Lesion size and form must be fully visible and accessible
- Willing and able to attend all study visits and follow instructions
- Good general health and oral hygiene
- Not taking any medication that affects salivary flow
- Provided written informed consent
Exclusion
- Evidence of tooth erosion
- Prior fluoride varnish application before study treatment
- Hypoplastic enamel defects or multiple restorations on facial surfaces of anterior teeth
- High caries risk patients
- Known or suspected allergy to milk proteins
- Use of medications affecting salivary flow
Key Trial Info
Start Date :
March 27 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2026
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT07146464
Start Date
March 27 2024
End Date
June 1 2026
Last Update
September 10 2025
Active Locations (1)
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1
Faculty of Dentistry, Ain Shams University
Cairo, Cairo Governorate, Egypt