Status:
NOT_YET_RECRUITING
Effect of Local Anesthetic Concentration on Rebound Pain: A Randomized Control Study
Lead Sponsor:
University of Virginia
Conditions:
Rebound Pain
Shoulder Arthroplasty
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Randomized control study that compares different concentrations of local anesthetic to investigate whether a lower concentration of local anesthetic would contribute to lower rebound pain scores at 24...
Eligibility Criteria
Inclusion
- Total shoulder replacement patients (anatomic and reverse)
- Adult patients (greater than or equal to 18 years)
- Any gender
- Any race
Exclusion
- \- Chronic Pain diagnoses including:
- substance/opioid use disorder
- complex regional pain syndromes
- fibromyalgia
- Daily persistent opioid use spanning 3 months prior to surgery date
- Allergy to local anesthetics or NSAIDS
- Respiratory pathologies including:
- CPAP- non-compliant / untreated obstructive sleep apnea
- COPD
- Restrictive lung disease (pulmonary fibrosis, interstitial pneumonia, etc)
- Contralateral diaphragm dysfunction
- BMI \> 40
- Ipsilateral extremity pre-existing nerve injury
- GFR \< 60
- NSAID contraindications
- Inability to follow up
- Revision surgery
- Patients requesting block as primary (avoidance of general anesthesia)
- Need or request for brachial plexus catheter or liposomal bupivacaine
- Vulnerable populations (pregnancy, incarceration, etc)
- non-English speaking
Key Trial Info
Start Date :
January 1 2026
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2029
Estimated Enrollment :
168 Patients enrolled
Trial Details
Trial ID
NCT07146685
Start Date
January 1 2026
End Date
January 1 2029
Last Update
August 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
UVA Health
Charlottesville, Virginia, United States, 22903