Status:
RECRUITING
Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts
Lead Sponsor:
Saglik Bilimleri Universitesi
Conditions:
Periodontitis
Intrabony Periodontal Defect
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain c...
Detailed Description
Intrabony defects are frequently observed in periodontitis patients. Bovine-derived xenogenic grafts are widely used in their treatment. To date, the graft has been mixed with various materials to inc...
Eligibility Criteria
Inclusion
- Male and female patients aged 18-65 years
- Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification
- PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment)
- Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm
- Non-smokers (those who smoke up to 10 per day may be included)
Exclusion
- Patients under 18 years of age or older than 65 years of age
- Patients unable to consent
- Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes
- Single-walled intrabony defects
- Those who have taken antibiotics, anti-inflammatory or immunosuppressive drugs, or birth control pills within the three months prior to the study
- Those who have received active periodontal treatment within the last six months and periodontal surgery within the last year
- Smoking more than 10 cigarettes per day
- Pregnancy or breastfeeding
- Those taking medications that affect the gums (e.g., calcium channel blockers, phenytoin or cyclosporine)
- Teeth with furcation defects
- Those undergoing active orthodontic treatment
- Those who are allergic to the biomaterials used in the study or prescribed medications
Key Trial Info
Start Date :
July 12 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT07146776
Start Date
July 12 2025
End Date
July 1 2026
Last Update
September 8 2025
Active Locations (1)
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1
Sağlık Bilimleri Üniversitesi
Istanbul, Üsküdar, Turkey (Türkiye)