Status:
RECRUITING
The Effect of a 6-month Dietitian-tailored Nutrition Intervention to Patients With Critical Illness (DETAIL)
Lead Sponsor:
University Hospital of North Norway
Collaborating Sponsors:
The Northern Norway Health Authority
Karolinska University Hospital
Conditions:
ICU Patients
Nutrition Intake
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This research project aims to study the effect of optimal and individualised nutrition to patients with critical illness during the intensive care unit (ICU) and hospital admission, and until six mont...
Detailed Description
The study will recruit patients with critical illness in one of two groups. Group one will receive standard nutrition care following the current local guidelines. Group two will receive frequent follo...
Eligibility Criteria
Inclusion
- Patients in intensive care who gives an informed consent and meet all of the following will be eligible:
- Admitted to the intensive care unit for \>48 hours.
- At least 18 years of age
- Have one or more organ system failure (respiratory,cardiovascular or renal) related to their acute illness defined as:
- a. PaO2/FiO2≤300 mm Hg) b. Currently on one or more continuous inotrope/vasopressor infusion which were started at least 4 hours ago at a minimum dose of: i. Norepinephrine≥0.1 mcg/kg/min ii. Epinephrine≥0.1 mcg/kg/min iii. Any dose of vasopressin iv. Milrinone\>0.1 mcg/kg/min) c. Renal dysfunction defined as: i. Serum creatinine 2.0-2.9 times baseline or ii. Urine output 0.5 mL/kg/hour for ≥12 hours or iii. Currently receiving renal replacement therapy) d. Currently has an intracranial pressure monitor or ventricular drain in situ
- Permanent living address in Norway
Exclusion
- Patients will be excluded if:
- Death is imminent in the next 96 hours or there is a current treatment limitation in place or the patient is unlikely to survive to 180 days due to underlying/chronic illness
- Dialysis dependent chronic renal failure
- Suspected or known pregnancy
- Wheelchair user
- Cognitive impairment in which intervention is considered not appropriate
- Eating disorders -
Key Trial Info
Start Date :
September 1 2025
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2028
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT07149246
Start Date
September 1 2025
End Date
March 31 2028
Last Update
September 3 2025
Active Locations (1)
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1
University Hospital of North Norway
Tromsø, Norway, 9037